Functional Basis of Sinus Bradycardia in Congenital Heart Block

Functional basis of sinus bradycardia in congenital heart block.

Congenital heart block (CHB) is a conduction abnormality characterized by complete atrioventricular (AV) block. CHB affects fetuses and/or newborn of mothers with autoantibodies reactive with ribonucleoproteins 48-kDa SSB/La, 52-kDa SSA/Ro, and 60-kDa SSA/Ro. We recently established animal models of CHB and reported, for the first time, significant sinus bradycardia preceding AV block. This une...

Neonatal congenital heart block.

Congenital Heart Block (CHB) is the most serious complication of neonatal lupus erythematosus. Transplasental transfer of maternal anti SSA/Ro or antiSSB/La antibodies around 12th week of gestation is associated with development of CHB. This may lead to inflammation, fibrosis and scarring of fetal conduction system in the early second trimester. Different degrees of atrioventricular (AV) block ...

Congenital complete heart block.

Congenital partial heart block.

Although congenital complete heart block is well recognized and has been fully reviewed, congenital partial heart block appears to be much more unusual. Howevev, a survey shows that several such cases have been described in America, but we have found only four cases recorded from this country. Whipham (1915) reported two, and Fleming and Stevenson (1928) gave an account of an eight-year-old gir...

Congenital Complete Heart Block.

Few of the reported cases of congenital complete heart block have been over twenty years of age. It seems, therefore, worth reporting seven cases who are in good health at various ages between 22 and 42 years. This aetiological factor should, therefore, be thought of in middle-aged and even in elderly patients with complete heart block of unknown oetiology. Campbell and Suzman (1934), reporting...